GHB has also been used legitimately as treatment for insomnia, narcolepsy, depression and to help wean people from alcohol. Initially it was synthesized in Europe and used as a general anesthetic however, its use was discontinued due to numerous adverse effects.
Hydroxocobalamin Sodium thiosulfate (25%)ħ0 mg/kg IV (max 5 g in 30 min) Can repeat up to 3 times 50 ml IVġ0 ml/kg IV over 30 min then 1.2 ml/kg/hr 15 mg/kg IV, then 10 mg/kg every 12 hrĢ g IM, or 15 mg/kg/hr IV (max dose, 6-8 g/day) SSRIs, dextromethorphan, TCAs, amphetaminesġ40 mg/kg po load, then 70 mg/kg every 4 hr for 17 dosesġ50 mg/kg IV load over 60 min then 50 mg/kg over 4 hr, then 100 mg/kg over 16 hrĠ.05 mg/kg IV bolus may repeat every 10 minġ00 ml IV over 1 min, then 400 ml IV over 20 minġ unit/kg bolus with 50 ml 50% dextrose followed by 1 unit/kg/hr with D10 W 200 ml/hrġ-2 g IV over 5-10 min, then 500 mg/hr infusion Increased muscle tone, hyperreflexia, clonus Hyperthermia, tachycardia, hypertension, tachypnea Miosis, salivation, lacrimation, diaphoresis, nausea, vomiting, urination, defecation, muscle fasciculations, weakness, seizures, arrhythmiaĪgitated but oriented, psychosis, anxiety Mydriasis, dry flushed skin, urinary retention, decreased bowel sounds, dry mucus membranes, seizuresĪtropine, antidepressants, antihistamines Hypotension, bradycardia, apnea, shallow breathing, hypothermia Mydriasis, tremor, increased peristalsis seizuresĬocaine, MDMA Mephedrone, Methamphetamine Hypertension, tachycardia hyperthermia, tachypnea
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